TRIB2 safeguards naive T cell homeostasis during aging

Summary: Naive CD4+ T cells are more resistant to age-related loss than naive CD8+ T cells, suggesting mechanisms that preferentially protect naive CD4+ T cells during aging.Here, we show that TRIB2 is more abundant in naive CD4+ than CD8+ T cells and counteracts quiescence exit by suppressing AKT activation.TRIB2 deficiency increases AKT activity

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Mechanisms by which adverse childhood experiences, other traumas and PTSD influence the health and well-being of individuals with eating disorders throughout the life span

Plain English summary Adverse childhood experiences (ACEs) and other traumatic experiences commonly occur in the great majority of individuals Shoes with EDs.The mechanisms by which ACEs and EDs emerge and interact with each other to lead to early death is reviewed from the perspective of the ACEs pyramid and the escalating cascade of problems that

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